Which antibiotic ointment is appropriate as first-line therapy for uncomplicated corneal abrasion in a patient without contact lens wear?

• A. Erythromycin Ointment
• B. Ciprofloxacin Eye Drops
• C. Prednisolone Drops
• D. No therapy

Answer: (A)

For an uncomplicated corneal abrasion in someone not wearing contact lenses, the priority is to prevent infection while the corneal epithelium re-epithelializes. A topical antibiotic ointment is a simple, effective way to provide prophylaxis, and its ointment form stays on the ocular surface longer, offering better coverage as the eye blinks.

Erythromycin ointment is a good first-line choice because it covers the common bacteria on the ocular surface, like Staphylococcus and Streptococcus, is easy to apply, and has a favorable safety profile. Ciprofloxacin eye drops, while broad-spectrum and strong against Pseudomonas, are typically reserved for contact lens wearers or when there’s suspicion of Pseudomonas or more severe infection. Steroid drops like prednisolone are not appropriate here because they can delay healing and undermine infection prevention. Leaving the abrasion without any therapy risks infection and slower healing, so prophylactic antibiotic ointment is the appropriate first step.